› 4hsv

X-ray diffraction
2.08Å resolution

Crystal Structure of CXCL4L1

Released:
DOI: 10.2210/pdb4hsv/pdb
PDB entry 4hsv coloured by chain, front view.
PDB entry 4hsv coloured by chain, side view.
PDB entry 4hsv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1.
Kuo JH, Chen YP, Liu JS, Dubrac A, Quemener C, Prats H, Bikfalvi A, Wu WG, Sue SC
J Biol Chem 288 13522-33 (2013)
PMID: 23536183

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145425 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet factor 4 variant Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 71 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10720 (Residues: 35-104; Coverage: 95%)
Gene names: CXCL4V1, PF4V1, SCYB4V1
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21212
Unit cell:
a: 75.672Å b: 55.18Å c: 68.134Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.272 0.236 0.278
Expression system: Escherichia coli

Quick links

Citations

8 review citations

CXCR3 ligands in disease and therapy.
Van Raemdonck et al. (2015)
7 more

8 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
7 more