› 4ht1

X-ray diffraction
2.5Å resolution

Human TWEAK in complex with the Fab fragment of a neutralizing antibody

Released:
DOI: 10.2210/pdb4ht1/pdb
PDB entry 4ht1 coloured by chain, front view.
PDB entry 4ht1 coloured by chain, side view.
PDB entry 4ht1 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding.
Lammens A, Baehner M, Kohnert U, Niewoehner J, von Proff L, Schraeml M, Lammens K, Hopfner KP
PLoS One 8 e62697 (2013)
PMID: 23667509

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208079 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tumor necrosis factor ligand superfamily member 12, secreted form Chain: T
Molecule details ›
Chain: T
Length: 154 amino acids
Theoretical weight: 17.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43508 (Residues: 97-249; Coverage: 61%)
Gene names: APO3L, DR3LG, TNFSF12, UNQ181/PRO207
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
chimeric antibody Fab Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.08 KDa
Source organism: Oryctolagus cuniculus
Structure domains: Immunoglobulins
chimeric antibody Fab Chain: L
Molecule details ›
Chain: L
Length: 218 amino acids
Theoretical weight: 23.62 KDa
Source organism: Oryctolagus cuniculus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3
Unit cell:
a: 101.63Å b: 101.63Å c: 57.582Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.183 0.211

Quick links

Citations

3 review citations

Is TWEAK a Biomarker for Autoimmune/Chronic Inflammatory Diseases?
Bertin et al. (2013)
2 more

9 mentions without citation

Improving B-cell epitope prediction and its application to global antibody-antigen docking.
Krawczyk et al. (2014)
8 more