› 4htm

X-ray diffraction
2Å resolution

Mechanism of CREB Recognition and Coactivation by the CREB Regulated Transcriptional Coactivator CRTC2

Released:
DOI: 10.2210/pdb4htm/pdb
PDB entry 4htm coloured by chain, front view.
PDB entry 4htm coloured by chain, side view.
PDB entry 4htm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation
Luo Q, Viste K, Urday-Zaa JC, Kumar GS, Tsai W-W, Talai A, Mayo K, Montminy M, Radhakrishnan I
Proc. Natl. Acad. Sci. U.S.A. (2012)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-176088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CREB-regulated transcription coactivator 2 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q53ET0 (Residues: 18-50; Coverage: 5%)
Gene names: CRTC2, TORC2
Sequence domains: Transducer of regulated CREB activity, N terminus

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 21.481Å b: 57.631Å c: 23.065Å
α: 90° β: 94.58° γ: 90°
R-values:
R R work R free
0.249 0.248 0.284
Expression system: Not provided

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