Function and Biology Details
Reaction catalysed:
(1a) ATP + [DNA ligase]-L-lysine = [DNA ligase]-N(6)-(5'-adenylyl)-L-lysine + diphosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Protein artemis and DNA ligase 4 (preferred)
PDBe Complex ID:
PDB-CPX-156093 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DNA ligase 4
Molecule details ›
Chains: A, B
Length: 240 amino acids
Theoretical weight: 27.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: DNA ligase N terminus
Structure domains: DNA ligase, ATP-dependent, N-terminal domain
Length: 240 amino acids
Theoretical weight: 27.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P49917 (Residues: 1-240; Coverage: 26%)
Sequence domains: DNA ligase N terminus
Structure domains: DNA ligase, ATP-dependent, N-terminal domain
Protein artemis
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X6A
Spacegroup:
P212121
Expression systems:
- Escherichia coli
- Not provided
