› 4hw5

X-ray diffraction
2.25Å resolution

Crystal Structure of the Human C3a anaphylatoxin

Released:
DOI: 10.2210/pdb4hw5/pdb
PDB entry 4hw5 coloured by chain, front view.
PDB entry 4hw5 coloured by chain, side view.
PDB entry 4hw5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg.
Bajic G, Yatime L, Klos A, Andersen GR
Protein Sci 22 204-12 (2013)
PMID: 23184394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-133821 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C3a anaphylatoxin Chains: A, B
Molecule details ›
Chains: A, B
Length: 83 amino acids
Theoretical weight: 9.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01024 (Residues: 672-748; Coverage: 5%)
Gene names: C3, CPAMD1
Sequence domains: Anaphylotoxin-like domain
Structure domains: Anaphylotoxins (complement system)

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P63
Unit cell:
a: 63.88Å b: 63.88Å c: 105.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.244 0.244 0.243
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
7 more

13 mentions without citation

Novel mechanisms and functions of complement.
Hajishengallis et al. (2017)
12 more