› 4i1p

X-ray diffraction
2.4Å resolution

Human MALT1 (caspase-IG3) in complex with activity based-probe

Released:
DOI: 10.2210/pdb4i1p/pdb
PDB entry 4i1p coloured by chain, front view.
PDB entry 4i1p coloured by chain, side view.
PDB entry 4i1p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.
Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D
Chem Biol 22 129-38 (2015)
PMID: 25556945

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-164562 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 388 amino acids
Theoretical weight: 44.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UDY8 (Residues: 339-719; Coverage: 46%)
Gene names: MALT1, MLT
Sequence domains:
Structure domains:
tetrapeptide Chains: B, D
Molecule details ›
Chains: B, D
Length: 5 amino acids
Theoretical weight: 750 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 10 x ACT
1 modified residue:
Ligand 4AR 2 x 4AR

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 178.243Å b: 53.482Å c: 78.74Å
α: 90° β: 103.8° γ: 90°
R-values:
R R work R free
0.201 0.198 0.245
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Jaworski et al. (2016)
1 more

3 mentions without citation

New targets for HIV drug discovery.
Puhl et al. (2019)
2 more