› 4i1r

X-ray diffraction
2.7Å resolution

Human MALT1 (caspase-IG3) in complex with thioridazine

Released:
DOI: 10.2210/pdb4i1r/pdb
PDB entry 4i1r coloured by chain, front view.
PDB entry 4i1r coloured by chain, side view.
PDB entry 4i1r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase.
Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP
Angew Chem Int Ed Engl 52 10384-7 (2013)
PMID: 23946259

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 44.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UDY8 (Residues: 339-719; Coverage: 46%)
Gene names: MALT1, MLT
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LZU 1 x LZU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2
Unit cell:
a: 94.838Å b: 70.608Å c: 57.525Å
α: 90° β: 93.63° γ: 90°
R-values:
R R work R free
0.205 0.201 0.249
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Jaworski et al. (2016)
8 more

2 mentions without citation

The CBM signalosome: potential therapeutic target for aggressive lymphoma?
Yang et al. (2014)
1 more