› 4i48

X-ray diffraction
2.8Å resolution

Structure of HLA-A68 complexed with an HIV Env derived peptide

Released:
DOI: 10.2210/pdb4i48/pdb
PDB entry 4i48 coloured by chain, front view.
PDB entry 4i48 coloured by chain, side view.
PDB entry 4i48 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 into the A2 and A3 supertypes.
Niu L, Cheng H, Zhang S, Tan S, Zhang Y, Qi J, Liu J, Gao GF
Mol Immunol 55 381-92 (2013)
PMID: 23566939

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137817 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 274 amino acids
Theoretical weight: 31.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-298; Coverage: 80%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Surface protein gp120 Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 925 Da
Source organism: Human immunodeficiency virus type 1 lw12.3 isolate
Expression system: Not provided
UniProt:
  • Canonical: Q70626 (Residues: 192-200; Coverage: 1%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 48.853Å b: 68.194Å c: 72.795Å
α: 90° β: 100.23° γ: 90°
R-values:
R R work R free
0.281 0.218 0.281
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

1 review citation

New vistas unfold: Chicken MHC molecules reveal unexpected ways to present peptides to the immune system.
Halabi et al. (2022)
8 other articles

5 mentions without citation

Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2.
Rakib et al. (2020)
4 more