› 4i79

X-ray diffraction
1.75Å resolution

Crystal structure of human NUP43

Released:
DOI: 10.2210/pdb4i79/pdb
PDB entry 4i79 coloured by chain, front view.
PDB entry 4i79 coloured by chain, side view.
PDB entry 4i79 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human nuclear pore complex component NUP43.
Xu C, Li Z, He H, Wernimont A, Li Y, Loppnau P, Min J
FEBS Lett 589 3247-53 (2015)
PMID: 26391640

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185528 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nucleoporin Nup43 Chains: A, B
Molecule details ›
Chains: A, B
Length: 399 amino acids
Theoretical weight: 44.23 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8NFH3 (Residues: 1-380; Coverage: 100%)
Gene name: NUP43
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
floating chain, unknown sequence Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 784 Da
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda

Ligands and Environments

1 bound ligand:
Ligand UNX 32 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P21212
Unit cell:
a: 80.736Å b: 161.964Å c: 58.197Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.212
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

The Nuclear Pore Complex as a Flexible and Dynamic Gate.
Knockenhauer et al. (2016)
1 more

4 mentions without citation

The Structure of the Nuclear Pore Complex (An Update).
Lin et al. (2019)
3 more