› 4iaa

X-ray diffraction
2.85Å resolution

Crystal structure of Ser/Thr kinase Pim1 in complex with thioridazine

Released:
DOI: 10.2210/pdb4iaa/pdb
PDB entry 4iaa coloured by chain, front view.
PDB entry 4iaa coloured by chain, side view.
PDB entry 4iaa coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhang W, Wan X, Li W, Xie Y, Huang N

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145753 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 289 amino acids
Theoretical weight: 33.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 29-313; Coverage: 91%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RTZ 1 x RTZ
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P65
Unit cell:
a: 98.817Å b: 98.817Å c: 80.507Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.231
Expression system: Escherichia coli

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