› 4ic8

X-ray diffraction
2.8Å resolution

Crystal structure of the apo ERK5 kinase domain

Released:
DOI: 10.2210/pdb4ic8/pdb
PDB entry 4ic8 coloured by chain, front view.
PDB entry 4ic8 coloured by chain, side view.
PDB entry 4ic8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.
Glatz G, Gógl G, Alexa A, Reményi A
J Biol Chem 288 8596-8609 (2013)
PMID: 23382384

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171583 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 442 amino acids
Theoretical weight: 49.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13164 (Residues: 1-431; Coverage: 53%)
Gene names: BMK1, ERK5, MAPK7, PRKM7
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P21
Unit cell:
a: 59.9Å b: 93.22Å c: 69.26Å
α: 90° β: 89.96° γ: 90°
R-values:
R R work R free
0.263 0.262 0.29
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Molecular basis of MAP kinase regulation.
Peti et al. (2013)
3 more

7 mentions without citation

Development of small molecule extracellular signal-regulated kinases (ERKs) inhibitors for cancer therapy.
Pan et al. (2022)
6 more