› 4ifn

X-ray diffraction
2.4Å resolution

Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes

Released:
DOI: 10.2210/pdb4ifn/pdb
PDB entry 4ifn coloured by chain, front view.
PDB entry 4ifn coloured by chain, side view.
PDB entry 4ifn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structures of apo Keap1, Keap1-peptide, and Keap1-compound complexes
Pan H, Lin M, Yang Y, Callaway K, Baker J, Diep L, Yan J, Tanaka K, Zhu YL, Konradi AW, Jobling M, Tam D, Ren Z, Cheung H, Bova M, Riley BE, Yao N, Artis DR
To be published

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171933 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chain: X
Molecule details ›
Chain: X
Length: 291 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14145 (Residues: 321-609; Coverage: 46%)
Gene names: INRF2, KEAP1, KIAA0132, KLHL19
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

1 bound ligand:
Ligand 12O 1 x 12O
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 124.878Å b: 75.258Å c: 48.754Å
α: 90° β: 106.34° γ: 90°
R-values:
R R work R free
0.278 0.274 0.352
Expression system: Escherichia coli

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