Function and Biology Details
Reaction catalysed:
(1a) [protein]-N(6)-acetyl-L-lysine + NAD(+) = [protein]-N(6)-(1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl)-L-lysine + nicotinamide
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
SirtT1 75 kDa fragment (preferred)
PDBe Complex ID:
PDB-CPX-188452 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SirtT1 75 kDa fragment
Molecule details ›
Chains: A, C, E, G
Length: 281 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Sir2 family
Structure domains:
Length: 281 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q96EB6 (Residues: 234-510; Coverage: 37%)
Sequence domains: Sir2 family
Structure domains:
NAD-dependent protein deacetylase sirtuin-1
Molecule details ›
Chains: B, D, F, H
Length: 31 amino acids
Theoretical weight: 3.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Length: 31 amino acids
Theoretical weight: 3.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q96EB6 (Residues: 641-665; Coverage: 3%)
