› 4iim

X-ray diffraction
1.8Å resolution

Crystal structure of the Second SH3 Domain of ITSN1 bound with a synthetic peptide

Released:
DOI: 10.2210/pdb4iim/pdb
PDB entry 4iim coloured by chain, front view.
PDB entry 4iim coloured by chain, side view.
PDB entry 4iim coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Guan X, Huang H, Wernimont A, Gu J, Sidhu S, Bountra C, Arrowsmith CH, Edwards AM, Tong Y, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164576 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Intersectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 70 amino acids
Theoretical weight: 7.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q15811 (Residues: 916-970; Coverage: 3%)
Gene names: ITSN, ITSN1, SH3D1A
Sequence domains: SH3 domain
Structure domains: SH3 Domains
peptide ligand Chains: C, D, E
Molecule details ›
Chains: C, D, E
Length: 12 amino acids
Theoretical weight: 1.44 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand UNX 11 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 41.048Å b: 51.393Å c: 69.26Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.243
Expression systems:
  • Escherichia coli BL21
  • Not provided

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