› 4im0

X-ray diffraction
2.4Å resolution

Structure of Tank-Binding Kinase 1

Released:
DOI: 10.2210/pdb4im0/pdb
PDB entry 4im0 coloured by chain, front view.
PDB entry 4im0 coloured by chain, side view.
PDB entry 4im0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and ubiquitination-dependent activation of TANK-binding kinase 1.
Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, Barbie DA, Eck MJ
Cell Rep 3 747-58 (2013)
PMID: 23453972

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193743 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase TBK1 Chain: A
Molecule details ›
Chain: A
Length: 663 amino acids
Theoretical weight: 76.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UHD2 (Residues: 1-657; Coverage: 90%)
Gene names: NAK, TBK1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1FV 1 x 1FV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P3221
Unit cell:
a: 133.921Å b: 133.921Å c: 85.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.236
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

The IκB kinase complex in NF-κB regulation and beyond.
Hinz et al. (2014)
26 more

13 mentions without citation

Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer.
Durand et al. (2018)
12 more