› 4is8

X-ray diffraction
2.78Å resolution

Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors

Released:
DOI: 10.2210/pdb4is8/pdb
PDB entry 4is8 coloured by chain, front view.
PDB entry 4is8 coloured by chain, side view.
PDB entry 4is8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors.
Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA
J Biol Chem 288 20702-12 (2013)
PMID: 23737522

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126306 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear receptor subfamily 5 group A member 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 239 amino acids
Theoretical weight: 27.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00482 (Residues: 300-538; Coverage: 44%)
Gene names: B1F, CPF, FTF, NR5A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 36.305Å b: 120.029Å c: 123.838Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.224 0.257
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Emerging roles of orphan nuclear receptors in cancer.
Baek et al. (2014)
1 more

2 mentions without citation

An approach to creating a more realistic working model from a protein data bank entry.
Brandon et al. (2015)
1 more