› 4ize

X-ray diffraction
2Å resolution

Crystal Structure of IL-36gamma

Released:
DOI: 10.2210/pdb4ize/pdb
PDB entry 4ize coloured by chain, front view.
PDB entry 4ize coloured by chain, side view.
PDB entry 4ize coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular determinants of agonist and antagonist signaling through the IL-36 receptor.
Günther S, Sundberg EJ
J Immunol 193 921-30 (2014)
PMID: 24935927

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-36 gamma Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZH8 (Residues: 18-169; Coverage: 90%)
Gene names: IL1E, IL1F9, IL1H1, IL1RP2, IL36G, UNQ2456/PRO5737
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CME 1 x CME

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P43212
Unit cell:
a: 89.315Å b: 89.315Å c: 37.879Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.225
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Regulation and function of interleukin-36 cytokines in homeostasis and pathological conditions.
Gabay et al. (2015)
14 more

7 mentions without citation

Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases.
Peñaloza et al. (2021)
6 more