› 4j6m

X-ray diffraction
2.48Å resolution

Crystal structure of calcium2+-free wild-type CD23 lectin domain (crystal form D)

Released:
DOI: 10.2210/pdb4j6m/pdb
PDB entry 4j6m coloured by chain, front view.
PDB entry 4j6m coloured by chain, side view.
PDB entry 4j6m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Dhaliwal B, Pang MO, Yuan D, Yahya N, Fabiane SM, McDonnell JM, Gould HJ, Beavil AJ, Sutton BJ
Mol Immunol 56 693-7 (2013)
PMID: 23933509

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin epsilon Fc receptor soluble form Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 143 amino acids
Theoretical weight: 16.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06734 (Residues: 156-298; Coverage: 45%)
Gene names: CD23A, CLEC4J, FCE2, FCER2, IGEBF
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 52.289Å b: 65.098Å c: 106.78Å
α: 95.26° β: 88.88° γ: 89.62°
R-values:
R R work R free
0.21 0.208 0.243
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.
Sutton et al. (2015)
3 more

1 mention without citation

Conformational plasticity at the IgE-binding site of the B-cell receptor CD23.
Dhaliwal et al. (2013)