› 4j7f

X-ray diffraction
1.59Å resolution

SET7/9Y335pAF in complex with TAF10 peptide and AdoHcy

Released:
DOI: 10.2210/pdb4j7f/pdb
PDB entry 4j7f coloured by chain, front view.
PDB entry 4j7f coloured by chain, side view.
PDB entry 4j7f coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Horowitz S, Del Rizzo PA, Trievel RC

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-171459 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone-lysine N-methyltransferase SETD7 Chain: A
Molecule details ›
Chain: A
Length: 261 amino acids
Theoretical weight: 29.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTS6 (Residues: 110-366; Coverage: 70%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Sequence domains:
Structure domains:
Transcription initiation factor TFIID subunit 10 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q12962 (Residues: 186-195; Coverage: 5%)
Gene names: TAF10, TAF2A, TAF2H, TAFII30

Ligands and Environments

1 bound ligand:
Ligand SAH 1 x SAH
1 modified residue:
Ligand HOX 1 x HOX

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P3221
Unit cell:
a: 83.046Å b: 83.046Å c: 95.524Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.201 0.215
Expression systems:
  • Escherichia coli
  • Not provided

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