› 4j8n

X-ray diffraction
3.14Å resolution

Aurora A Kinase Apo

Released:
DOI: 10.2210/pdb4j8n/pdb
PDB entry 4j8n coloured by chain, front view.
PDB entry 4j8n coloured by chain, side view.
PDB entry 4j8n coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Drugging MYCN through an allosteric transition in Aurora kinase A.
Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA
Cancer Cell 26 414-427 (2014)
PMID: 25175806

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 279 amino acids
Theoretical weight: 32.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14965 (Residues: 123-401; Coverage: 69%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P31
Unit cell:
a: 83.783Å b: 83.783Å c: 171.777Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.184 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

61 review citations

Neuroblastoma.
Matthay et al. (2016)
60 more

5 mentions without citation

Drugging MYCN through an allosteric transition in Aurora kinase A.
Gustafson et al. (2014)
4 more