› 4ja8

X-ray diffraction
1.55Å resolution

Function and Biology Details

Reaction catalysed: 
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155800 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isocitrate dehydrogenase [NADP], mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 416 amino acids
Theoretical weight: 47.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P48735 (Residues: 41-452; Coverage: 91%)
Gene name: IDH2
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Structure domains: Isopropylmalate Dehydrogenase

Ligands and Environments


Cofactor: Ligand NDP 2 x NDP
3 bound ligands:
Ligand 1K9 1 x 1K9
Ligand CA 2 x CA
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 58.656Å b: 119.661Å c: 125.542Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.218
Expression system: Not provided

Quick links

Citations

276 review citations

The Emerging Hallmarks of Cancer Metabolism.
Pavlova et al. (2016)
275 more

13 mentions without citation

Impact of the Protein Data Bank on antineoplastic approvals.
Westbrook et al. (2020)
12 more