› 4jds

X-ray diffraction
1.7Å resolution

SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine

Released:
DOI: 10.2210/pdb4jds/pdb
PDB entry 4jds coloured by chain, front view.
PDB entry 4jds coloured by chain, side view.
PDB entry 4jds coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dong A, Wu H, Zeng H, Park H, El Bakkouri M, Barsyte D, Vedadi M, Tatlock J, Owen D, Bunnage M, Bountra C, Arrowsmith CH, Edwards AM, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase SETD7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 264 amino acids
Theoretical weight: 29.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTS6 (Residues: 109-366; Coverage: 71%)
Gene names: KIAA1717, KMT7, SET7, SET9, SETD7
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SAM 4 x SAM
Ligand 1L4 4 x 1L4
Ligand UNX 37 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2221
Unit cell:
a: 118.048Å b: 134.482Å c: 137.255Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.223
Expression system: Escherichia coli

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