› 4jpj

X-ray diffraction
2.5Å resolution

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6

Released:
DOI: 10.2210/pdb4jpj/pdb
PDB entry 4jpj coloured by chain, front view.
PDB entry 4jpj coloured by chain, side view.
PDB entry 4jpj coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Rational HIV immunogen design to target specific germline B cell receptors.
Jardine J, Julien JP, Menis S, Ota T, Kalyuzhniy O, McGuire A, Sok D, Huang PS, MacPherson S, Jones M, Nieusma T, Mathison J, Baker D, Ward AB, Burton DR, Stamatatos L, Nemazee D, Wilson IA, Schief WR
Science 340 711-6 (2013)
PMID: 23539181

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137921 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Surface protein gp120 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 181 amino acids
Theoretical weight: 20 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 254-399; Coverage: 14%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120

Ligands and Environments

1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 44.96Å b: 217.73Å c: 44.99Å
α: 90° β: 119.97° γ: 90°
R-values:
R R work R free
0.212 0.21 0.262
Expression system: Homo sapiens

Quick links

Citations

164 review citations

HIV infection: epidemiology, pathogenesis, treatment, and prevention.
Maartens et al. (2014)
163 more

1 mention without citation

Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
Jardine et al. (2016)