› 4jup

X-ray diffraction
3.2Å resolution

Dimeric structure of CARMA1 CARD

Released:
DOI: 10.2210/pdb4jup/pdb
PDB entry 4jup coloured by chain, front view.
PDB entry 4jup coloured by chain, side view.
PDB entry 4jup coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Novel disulfide bond-mediated dimerization of the CARD domain was revealed by the crystal structure of CARMA1 CARD.
Jang TH, Park JH, Park HH
PLoS One 8 e79778 (2013)
PMID: 24224005

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase recruitment domain-containing protein 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 12.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXL7 (Residues: 21-116; Coverage: 8%)
Gene names: CARD11, CARMA1
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 45.887Å b: 53.863Å c: 92.802Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.264 0.259 0.388
Expression system: Escherichia coli

Quick links

Citations

2 review citations

The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.
Kao et al. (2015)
1 more

4 mentions without citation

Activation and assembly of the inflammasomes through conserved protein domain families.
Jin et al. (2015)
3 more