› 4jyo

X-ray diffraction
2.5Å resolution

Structural basis for angiopoietin-1 mediated signaling initiation

Released:
DOI: 10.2210/pdb4jyo/pdb
PDB entry 4jyo coloured by chain, front view.
PDB entry 4jyo coloured by chain, side view.
PDB entry 4jyo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for angiopoietin-1-mediated signaling initiation.
Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA
Proc Natl Acad Sci U S A 110 7205-10 (2013)
PMID: 23592718

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-172274 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-1 Chain: X
Molecule details ›
Chain: X
Length: 230 amino acids
Theoretical weight: 26.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q15389 (Residues: 280-498; Coverage: 45%)
Gene names: ANGPT1, KIAA0003
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P6422
Unit cell:
a: 80.968Å b: 80.968Å c: 187.216Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.242
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Therapeutic targeting of the angiopoietin-TIE pathway.
Saharinen et al. (2017)
13 more

4 mentions without citation

Structural basis for angiopoietin-1-mediated signaling initiation.
Yu et al. (2013)
3 more