› 4jzc

X-ray diffraction
1.9Å resolution

Angiopoietin-2 fibrinogen domain TAG mutant

Released:
DOI: 10.2210/pdb4jzc/pdb
PDB entry 4jzc coloured by chain, front view.
PDB entry 4jzc coloured by chain, side view.
PDB entry 4jzc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for angiopoietin-1-mediated signaling initiation.
Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA
Proc Natl Acad Sci U S A 110 7205-10 (2013)
PMID: 23592718

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-127303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-2 Chain: A
Molecule details ›
Chain: A
Length: 218 amino acids
Theoretical weight: 24.82 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15123 (Residues: 279-496; Coverage: 46%)
Gene name: ANGPT2
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: I222
Unit cell:
a: 46.692Å b: 79.055Å c: 135.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.23 0.248
Expression system: Homo sapiens

Quick links

Citations

14 review citations

Therapeutic targeting of the angiopoietin-TIE pathway.
Saharinen et al. (2017)
13 more

2 mentions without citation

Structural basis for angiopoietin-1-mediated signaling initiation.
Yu et al. (2013)
1 more