› 4jzj

X-ray diffraction
2.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210927 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Interleukin-3 receptor subunit alpha Chains: C, D
Molecule details ›
Chains: C, D
Length: 287 amino acids
Theoretical weight: 33.1 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P26951 (Residues: 20-307; Coverage: 80%)
Gene names: IL3R, IL3RA
Sequence domains:
Structure domains:
Fab Heavy Chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 221 amino acids
Theoretical weight: 23.8 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
Fab Light Chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 220 amino acids
Theoretical weight: 24.26 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, FUL, FUC
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 88.3Å b: 120.648Å c: 92.968Å
α: 90° β: 97.45° γ: 90°
R-values:
R R work R free
0.188 0.185 0.244
Expression system: Spodoptera frugiperda

Quick links

Citations

10 review citations

JAK2 activation by growth hormone and other cytokines.
Waters et al. (2015)
9 more

6 mentions without citation

Computationally-driven identification of antibody epitopes.
Hua et al. (2017)
5 more