4k07

X-ray diffraction
2.83Å resolution

Crystal structure of the amyloid-forming immunoglobulin AL-103 cis-proline 95 mutant

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134444 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin kappa variable 1-33 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 129 amino acids
Theoretical weight: 14.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01594 (Residues: 3-14, 15-19, 20-117; Coverage: 98%)
Gene name: IGKV1-33
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21212
Unit cell:
a: 159.91Å b: 200.334Å c: 40.056Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.236
Expression system: Escherichia coli