› 4k0r

X-ray diffraction
2.65Å resolution

Crystal structure of mouse Cryptochrome 1

Released:
DOI: 10.2210/pdb4k0r/pdb
PDB entry 4k0r coloured by chain, front view.
PDB entry 4k0r coloured by chain, side view.
PDB entry 4k0r coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structures of Drosophila cryptochrome and mouse cryptochrome1 provide insight into circadian function.
Czarna A, Berndt A, Singh HR, Grudziecki A, Ladurner AG, Timinszky G, Kramer A, Wolf E
Cell 153 1394-405 (2013)
PMID: 23746849

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161322 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cryptochrome-1 Chain: A
Molecule details ›
Chain: A
Length: 617 amino acids
Theoretical weight: 69.37 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P97784 (Residues: 1-606; Coverage: 100%)
Gene name: Cry1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 44.17Å b: 79.55Å c: 127.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.19 0.26
Expression system: Spodoptera frugiperda

Quick links

Citations

24 review citations

Molecular architecture of the mammalian circadian clock.
Partch et al. (2014)
23 more

9 mentions without citation

Emerging models for the molecular basis of mammalian circadian timing.
Gustafson et al. (2015)
8 more