› 4k7a

X-ray diffraction
2.44Å resolution

Crystal structure of the androgen receptor ligand binding domain in complex with minoxidil

Released:
DOI: 10.2210/pdb4k7a/pdb
PDB entry 4k7a coloured by chain, front view.
PDB entry 4k7a coloured by chain, side view.
PDB entry 4k7a coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Liu JS, Hsu CL, Wu WG

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Androgen receptor Chain: A
Molecule details ›
Chain: A
Length: 249 amino acids
Theoretical weight: 28.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10275 (Residues: 671-919; Coverage: 27%)
Gene names: AR, DHTR, NR3C4
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand DHT 1 x DHT
Ligand MXD 1 x MXD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13C1
Spacegroup: P212121
Unit cell:
a: 55.429Å b: 65.541Å c: 70.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.188 0.268
Expression system: Escherichia coli

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