› 4k7f

X-ray diffraction
2Å resolution

Newly identified epitope V60 from HBV core protein complexed with HLA-A*0201

Released:
DOI: 10.2210/pdb4k7f/pdb
PDB entry 4k7f coloured by chain, front view.
PDB entry 4k7f coloured by chain, side view.
PDB entry 4k7f coloured by chain, top view.
Source organisms:
Primary publication:
The L60V variation in hepatitis B virus core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication.
Zhang Y, Ren Y, Wu Y, Zhao B, Qiu L, Li X, Xu D, Liu J, Gao GF, Meng S
J Virol 87 8075-84 (2013)
PMID: 23678186

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137830 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Sequence domains:
Structure domains:
Beta-2-microglobulin Chains: B, E
Molecule details ›
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Capsid protein Chains: C, F
Molecule details ›
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.06 KDa
Source organism: Hepatitis B virus
Expression system: Not provided
UniProt:
  • Canonical: Q9QAC5 (Residues: 60-68; Coverage: 5%)
Gene name: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 83.864Å b: 58.552Å c: 89.581Å
α: 90° β: 109.86° γ: 90°
R-values:
R R work R free
0.207 0.204 0.259
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

Genetic variation of hepatitis B virus and its significance for pathogenesis.
Zhang et al. (2016)
2 more

3 mentions without citation

Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.
Song et al. (2017)
2 more