› 4kbo

X-ray diffraction
2.8Å resolution

Crystal structure of the human Mortalin (GRP75) ATPase domain in the apo form

Released:
DOI: 10.2210/pdb4kbo/pdb
PDB entry 4kbo coloured by chain, front view.
PDB entry 4kbo coloured by chain, side view.
PDB entry 4kbo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the nucleotide-binding domain of mortalin, the mitochondrial Hsp70 chaperone.
Amick J, Schlanger SE, Wachnowsky C, Moseng MA, Emerson CC, Dare M, Luo WI, Ithychanda SS, Nix JC, Cowan JA, Page RC, Misra S
Protein Sci 23 833-42 (2014)
PMID: 24687350

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stress-70 protein, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 385 amino acids
Theoretical weight: 41.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P38646 (Residues: 52-431; Coverage: 56%)
Gene names: GRP75, HSPA9, HSPA9B, mt-HSP70
Sequence domains: Hsp70 protein
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 51.197Å b: 67.812Å c: 120.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.271
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Protein networks in the maturation of human iron-sulfur proteins.
Ciofi-Baffoni et al. (2018)
5 more

21 mentions without citation

Abrogating the Interaction Between p53 and Mortalin (Grp75/HSPA9/mtHsp70) for Cancer Therapy: The Story so far.
Elwakeel A. (2022)
20 more