› 4kg8

X-ray diffraction
2.25Å resolution

Crystal structure of light mutant

Released:
DOI: 10.2210/pdb4kg8/pdb
PDB entry 4kg8 coloured by chain, front view.
PDB entry 4kg8 coloured by chain, side view.
PDB entry 4kg8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Liu W, Zhan C, Cheng H, Kumar PR, Bonanno JB, Nathenson SG, Almo SC
Structure 22 1252-1262 (2014)
PMID: 25087510

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 14, soluble form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 158 amino acids
Theoretical weight: 17.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43557 (Residues: 83-240; Coverage: 66%)
Gene names: HVEML, LIGHT, TNFSF14, UNQ391/PRO726
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 59.644Å b: 46.911Å c: 70.4Å
α: 90° β: 98.02° γ: 90°
R-values:
R R work R free
0.215 0.211 0.286
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses.
Ward-Kavanagh et al. (2016)
4 more

2 mentions without citation

Mechanistic basis for functional promiscuity in the TNF and TNF receptor superfamilies: structure of the LIGHT:DcR3 assembly.
Liu et al. (2014)
1 more