› 4kkj

X-ray diffraction
3Å resolution

Crystal Structure of Haptocorrin in Complex with Cbi

Released:
DOI: 10.2210/pdb4kkj/pdb
PDB entry 4kkj coloured by chain, front view.
PDB entry 4kkj coloured by chain, side view.
PDB entry 4kkj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.
Furger E, Frei DC, Schibli R, Fischer E, Prota AE
J Biol Chem 288 25466-25476 (2013)
PMID: 23846701

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcobalamin-1 Chain: A
Molecule details ›
Chain: A
Length: 467 amino acids
Theoretical weight: 52.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P20061 (Residues: 1-433; Coverage: 100%)
Gene names: TC1, TCN1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 7 x NAG
Ligand CBY 1 x CBY
Ligand CYN 2 x CYN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P64
Unit cell:
a: 150.378Å b: 150.378Å c: 60.275Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.252
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Vitamin B-12 and Perinatal Health.
Finkelstein et al. (2015)
4 more

1 mention without citation

Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin.
Furger et al. (2013)