› 4kla

X-ray diffraction
2.6Å resolution

E343D variant of human ferrochelatase

Released:
DOI: 10.2210/pdb4kla/pdb
PDB entry 4kla coloured by chain, front view.
PDB entry 4kla coloured by chain, side view.
PDB entry 4kla coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lanzilotta WN, Medlock AE

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferrochelatase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 41.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22830 (Residues: 65-423; Coverage: 85%)
Gene name: FECH
Sequence domains: Ferrochelatase
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand CHD 3 x CHD
Ligand GOL 1 x GOL
Ligand FES 2 x FES
Ligand PP9 1 x PP9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 87.993Å b: 93.429Å c: 111.739Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.285
Expression system: Escherichia coli

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