› 4km6

X-ray diffraction
1.55Å resolution

Human folate receptor alpha (FOLR1) at acidic pH, orthorhombic form

Released:
DOI: 10.2210/pdb4km6/pdb
PDB entry 4km6 coloured by chain, front view.
PDB entry 4km6 coloured by chain, side view.
PDB entry 4km6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE
Proc Natl Acad Sci U S A 110 15180-8 (2013)
PMID: 23934049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Folate receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 208 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P15328 (Residues: 30-234; Coverage: 88%)
Gene names: FOLR, FOLR1
Sequence domains: Folate receptor family

Ligands and Environments

2 bound ligands:
Ligand CA 1 x CA
Ligand NAG 3 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P212121
Unit cell:
a: 36.519Å b: 63.339Å c: 71.169Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.2
Expression system: Cricetulus griseus

Quick links

Citations

14 review citations

The folate receptor as a rational therapeutic target for personalized cancer treatment.
Assaraf et al. (2014)
13 more

2 mentions without citation

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo et al. (2013)
1 more