› 4kmh

X-ray diffraction
3.04Å resolution

Crystal structure of Suppressor of Fused d20

Released:
DOI: 10.2210/pdb4kmh/pdb
PDB entry 4kmh coloured by chain, front view.
PDB entry 4kmh coloured by chain, side view.
PDB entry 4kmh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y, Wu G
Nat Commun 4 2608 (2013)
PMID: 24217340

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193975 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Suppressor of fused homolog Chains: A, B
Molecule details ›
Chains: A, B
Length: 484 amino acids
Theoretical weight: 53.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UMX1 (Residues: 1-484; Coverage: 96%)
Gene names: SUFU, UNQ650/PRO1280
Sequence domains:
Structure domains: Sufu, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 73.634Å b: 122.329Å c: 118.751Å
α: 90° β: 90.41° γ: 90°
R-values:
R R work R free
0.227 0.224 0.277
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Hedgehog Signaling: From Basic Biology to Cancer Therapy.
Wu et al. (2017)
10 more

1 mention without citation

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Zhang et al. (2013)