› 4kmn

X-ray diffraction
1.52Å resolution

Structure of cIAP1-BIR3 and inhibitor

Released:
DOI: 10.2210/pdb4kmn/pdb
PDB entry 4kmn coloured by chain, front view.
PDB entry 4kmn coloured by chain, side view.
PDB entry 4kmn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li X, Wang J, Condon SM, Shi Y

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Baculoviral IAP repeat-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 103 amino acids
Theoretical weight: 11.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13490 (Residues: 260-357; Coverage: 16%)
Gene names: API1, BIRC2, MIHB, RNF48
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

Ligands and Environments

3 bound ligands:
Ligand ZN 1 x ZN
Ligand 436 1 x 436
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3221
Unit cell:
a: 67.714Å b: 67.714Å c: 66.913Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.161 0.16 0.199
Expression system: Escherichia coli

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