› 4kmp

X-ray diffraction
1.95Å resolution

Structure of XIAP-BIR3 and inhibitor

Released:
DOI: 10.2210/pdb4kmp/pdb
PDB entry 4kmp coloured by chain, front view.
PDB entry 4kmp coloured by chain, side view.
PDB entry 4kmp coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li X, Wang J, Condon SM, Shi Y

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161361 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase XIAP Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P98170 (Residues: 256-348; Coverage: 19%)
Gene names: API3, BIRC4, IAP3, XIAP
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand GT6 1 x GT6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 32.016Å b: 33.281Å c: 48.002Å
α: 77.97° β: 70.54° γ: 61.28°
R-values:
R R work R free
0.165 0.162 0.219
Expression system: Escherichia coli

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