› 4kmx

X-ray diffraction
2.2Å resolution

Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form

Released:
DOI: 10.2210/pdb4kmx/pdb
PDB entry 4kmx coloured by chain, front view.
PDB entry 4kmx coloured by chain, side view.
PDB entry 4kmx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo AS, Singh M, Reeder KM, Carter JJ, Kovach AR, Meng W, Ratnam M, Zhang F, Dann CE
Proc Natl Acad Sci U S A 110 15180-8 (2013)
PMID: 23934049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147318 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Folate receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 24.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15328 (Residues: 28-234; Coverage: 89%)
Gene names: FOLR, FOLR1
Sequence domains: Folate receptor family

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
3 bound ligands:
Ligand K 1 x K
Ligand CL 1 x CL
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P65
Unit cell:
a: 99.193Å b: 99.193Å c: 56.869Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.168 0.166 0.206
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

The folate receptor as a rational therapeutic target for personalized cancer treatment.
Assaraf et al. (2014)
13 more

1 mention without citation

Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition.
Wibowo et al. (2013)