› 4ks7

X-ray diffraction
1.4Å resolution

PAK6 kinase domain in complex with PF-3758309

Released:
DOI: 10.2210/pdb4ks7/pdb
PDB entry 4ks7 coloured by chain, front view.
PDB entry 4ks7 coloured by chain, side view.
PDB entry 4ks7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.
Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ
PLoS One 8 e77818 (2013)
PMID: 24204982

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 6 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQU5 (Residues: 385-674; Coverage: 43%)
Gene names: PAK5, PAK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IPA 1 x IPA
Ligand 7KC 1 x 7KC
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P212121
Unit cell:
a: 48.573Å b: 59.709Å c: 100.541Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.217
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.
Ha et al. (2015)
3 more

2 mentions without citation

Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.
Gao et al. (2013)
1 more