› 4ks8

X-ray diffraction
1.95Å resolution

PAK6 kinase domain in complex with sunitinib

Released:
DOI: 10.2210/pdb4ks8/pdb
PDB entry 4ks8 coloured by chain, front view.
PDB entry 4ks8 coloured by chain, side view.
PDB entry 4ks8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6.
Gao J, Ha BH, Lou HJ, Morse EM, Zhang R, Calderwood DA, Turk BE, Boggon TJ
PLoS One 8 e77818 (2013)
PMID: 24204982

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192514 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PAK 6 Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NQU5 (Residues: 385-674; Coverage: 43%)
Gene names: PAK5, PAK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand B49 1 x B49
1 modified residue:
Ligand SEP 1 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 49.616Å b: 60.099Å c: 99.979Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.261
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Signaling, Regulation, and Specificity of the Type II p21-activated Kinases.
Ha et al. (2015)
2 more

6 mentions without citation

Kinases as targets for chemical modulators: Structural aspects and their role in spermatogenesis.
Jenardhanan et al. (2014)
5 more