› 4ku1

X-ray diffraction
1.9Å resolution

Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering

Released:
DOI: 10.2210/pdb4ku1/pdb
PDB entry 4ku1 coloured by chain, front view.
PDB entry 4ku1 coloured by chain, side view.
PDB entry 4ku1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering.
Frank M, Walker RC, Lanzilotta WN, Prestegard JH, Barb AW
J. Mol. Biol. (2014)
PMID: 24522230

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 208 amino acids
Theoretical weight: 23.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 120-327; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
Carbohydrate polymer
1 bound ligand:
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 49.145Å b: 79.865Å c: 128.402Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.212 0.258

Quick links

Citations

10 review citations

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.
Caaveiro et al. (2015)
9 more

7 mentions without citation

A perspective on the structure and receptor binding properties of immunoglobulin G Fc.
Hanson et al. (2015)
6 more