› 4kwp

X-ray diffraction
1.25Å resolution

Crystal Structure of Human CK2-alpha in complex with a benzimidazole inhibitor (K164) at 1.25 A resolution

Released:
DOI: 10.2210/pdb4kwp/pdb
PDB entry 4kwp coloured by chain, front view.
PDB entry 4kwp coloured by chain, side view.
PDB entry 4kwp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.
Cozza G, Girardi C, Ranchio A, Lolli G, Sarno S, Orzeszko A, Kazimierczuk Z, Battistutta R, Ruzzene M, Pinna LA
Cell Mol Life Sci 71 3173-85 (2014)
PMID: 24442476

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 336 amino acids
Theoretical weight: 40.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P68400 (Residues: 1-336; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand SO4 4 x SO4
Ligand EDO 3 x EDO
Ligand EXX 1 x EXX
Ligand PGE 1 x PGE
Ligand PEG 1 x PEG
Ligand DMS 1 x DMS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P21
Unit cell:
a: 58.448Å b: 45.821Å c: 63.486Å
α: 90° β: 111.15° γ: 90°
R-values:
R R work R free
0.138 0.136 0.17
Expression system: Escherichia coli BL21

Quick links

Citations

8 review citations

Protein kinase CK2: a potential therapeutic target for diverse human diseases.
Borgo et al. (2021)
7 more

3 mentions without citation

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine.
Lee et al. (2023)
2 more