› 4l1d

X-ray diffraction
2.5Å resolution

Voltage-gated sodium channel beta3 subunit Ig domain

Released:
DOI: 10.2210/pdb4l1d/pdb
PDB entry 4l1d coloured by chain, front view.
PDB entry 4l1d coloured by chain, side view.
PDB entry 4l1d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and molecular imaging of the Nav channel β3 subunit indicates a trimeric assembly.
Namadurai S, Balasuriya D, Rajappa R, Wiemhöfer M, Stott K, Klingauf J, Edwardson JM, Chirgadze DY, Jackson AP
J Biol Chem 289 10797-10811 (2014)
PMID: 24567321

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192696 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium channel regulatory subunit beta-3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 127 amino acids
Theoretical weight: 14.83 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NY72 (Residues: 25-145; Coverage: 63%)
Gene names: KIAA1158, SCN3B
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 81.469Å b: 81.469Å c: 114.257Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.202 0.238
Expression system: Homo sapiens

Quick links

Citations

16 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
15 more

8 mentions without citation

A new look at sodium channel β subunits.
Namadurai et al. (2015)
7 more