› 4l1t

X-ray diffraction
1.16Å resolution

Transthyretin in complex with (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzoic acid

Released:
DOI: 10.2210/pdb4l1t/pdb
PDB entry 4l1t coloured by chain, front view.
PDB entry 4l1t coloured by chain, side view.
PDB entry 4l1t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn.
Baranczak A, Connelly S, Liu Y, Choi S, Grimster NP, Powers ET, Wilson IA, Kelly JW
Biopolymers 101 484-95 (2014)
PMID: 24105107

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand 1WZ 2 x 1WZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21212
Unit cell:
a: 42.305Å b: 85.551Å c: 63.006Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.188
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Sulfonyl fluorides as privileged warheads in chemical biology.
Narayanan et al. (2015)
2 more

1 mention without citation

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging--what we know and what we need to learn.
Baranczak et al. (2014)