› 4l3j

X-ray diffraction
2.1Å resolution

Crystal structures of human p70S6K1 kinase domain

Released:
DOI: 10.2210/pdb4l3j/pdb
PDB entry 4l3j coloured by chain, front view.
PDB entry 4l3j coloured by chain, side view.
PDB entry 4l3j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.
Wang J, Zhong C, Wang F, Qu F, Ding J
Biochem J 454 39-47 (2013)
PMID: 23731517

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase beta-1 Chain: A
Molecule details ›
Chain: A
Length: 304 amino acids
Theoretical weight: 34.34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23443 (Residues: 75-375; Coverage: 57%)
Gene names: RPS6KB1, STK14A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 5FI 1 x 5FI
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 70.511Å b: 70.511Å c: 150.484Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.21 0.255
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Hypoxia and aging.
Yeo EJ. (2019)
2 more

6 mentions without citation

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities.
Galat A. (2017)
5 more