› 4l46

X-ray diffraction
3.01Å resolution

Crystal structures of human p70S6K1-WT

Released:
DOI: 10.2210/pdb4l46/pdb
PDB entry 4l46 coloured by chain, front view.
PDB entry 4l46 coloured by chain, side view.
PDB entry 4l46 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of S6K1 provide insights into the regulation mechanism of S6K1 by the hydrophobic motif.
Wang J, Zhong C, Wang F, Qu F, Ding J
Biochem J 454 39-47 (2013)
PMID: 23731517

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase beta-1 Chain: A
Molecule details ›
Chain: A
Length: 346 amino acids
Theoretical weight: 39.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23443 (Residues: 75-417; Coverage: 65%)
Gene names: RPS6KB1, STK14A
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 5FI 1 x 5FI
Ligand SO4 1 x SO4
Ligand ZN 1 x ZN
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3221
Unit cell:
a: 81.139Å b: 81.139Å c: 111.047Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.217 0.269
Expression system: Spodoptera frugiperda

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Citations

4 review citations

The structural basis for mTOR function.
Baretić et al. (2014)
3 more