› 4l93

X-ray diffraction
1.84Å resolution

Crystal structure of Human Hsp90 with S36

Released:
DOI: 10.2210/pdb4l93/pdb
PDB entry 4l93 coloured by chain, front view.
PDB entry 4l93 coloured by chain, side view.
PDB entry 4l93 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li J, Ren J, Yang M, Xiong B, He J

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139824 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 228 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 9-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand S36 2 x S36
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 64.319Å b: 88.83Å c: 98.181Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.26
Expression system: Escherichia coli

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