› 4l9c

X-ray diffraction
2.1Å resolution

Crystal structure of the FP domain of human F-box protein Fbxo7 (native)

Released:
DOI: 10.2210/pdb4l9c/pdb
PDB entry 4l9c coloured by chain, front view.
PDB entry 4l9c coloured by chain, side view.
PDB entry 4l9c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the FP domain of Fbxo7 reveals a novel mode of protein-protein interaction.
Shang J, Wang G, Yang Y, Huang X, Du Z
Acta Crystallogr D Biol Crystallogr 70 155-64 (2014)
PMID: 24419388

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195209 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
F-box only protein 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 160 amino acids
Theoretical weight: 17.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y3I1 (Residues: 180-335; Coverage: 30%)
Gene names: FBX7, FBXO7
Sequence domains: PI31 proteasome regulator N-terminal
Structure domains: Protein Transport Mog1p; Chain A

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P212121
Unit cell:
a: 44.22Å b: 64.41Å c: 89.31Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.191 0.247
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Spo0M: structure and function beyond regulation of sporulation.
Vega-Cabrera et al. (2018)
2 other articles

1 mention without citation

Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Liu et al. (2020)